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Cayman Chemical MethIonIn SulfoxID PolycLN 1ea
Supplier: Cayman Chemical 6001661 EA
An antiemetic and antagonist of dopamine D2- D4- and D3 receptors (Kis 1365 691 and 545 nM for a2A- a2B- and a2C-AR respectively) has been mistakenly identified as an antagonist of histamine H1 receptors and M1-5 mAChRs inhibits conditioned avoidance in the shuttle box test in dogs (ED50 2.77 mg/kg) inhibits apomorphine-induced emesis in dogs (ED50 0.69 mg/kg) induces tachycardia increases blood levels of norepinephrine and temporarily decreases systolic and diastolic blood pressure which revert to baseline within one minute in normotensive dogs at 0.5-5 mg/kg
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