Methotrexate disodium salt, 98.5%

Description

Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities. | CAS: 7413-34-5 | C20H20N8Na2O5 | 498.411 g/mol

Inhibits the metabolism of folic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities

• It acts as an enzyme inhibitor of dihydrofolate reductase

• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor

Application

• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism

• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites

• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice

Specifications

Chemical Identifiers

• CAS: 7413-34-5
• Molecular Formula: C20H20N8Na2O5
• Molecular Weight (g/mol): 498.411
• MDL Number: MFCD00274560
• InChI Key: DASQOOZCTWOQPA-GXKRWWSZSA-L
• Synonym: methotrexate disodium salt, sodium methotrexate, ledertrexate, methotrexate sodium, mtx disodium, methotrexate disodium, unii-3ig1e710zn, trexall, mexate, methotrexate lpf
• PubChem CID: 11329481
• ChEBI: CHEBI:50679
• IUPAC Name: disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

• Color: Yellow
• Boiling Point: 823°C
• Quantity: 250 mg
• UN Number: UN2811
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in water
• Formula Weight: 498.4
• Percent Purity: 98.5%
• Physical Form: Powder
• Chemical Name or Material: Methotrexate disodium salt

Safety and Handling

Hazard Category	H301-H315-H319
Hazard Statement	GHS H Statement H301 Toxic if swallowed.
Precautionary Statement	P264b-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c
DOTInformation	Hazard Class: 6.1
EINECSNumber	231-022-0
RTECSNumber	MA1232000
TSCA	No
storageNote1	2° to 8°C
Recommended Storage	Keep cold; Store under Argon

SDS

RUO – Research Use Only