Methotrexate

Description

CAS: 59-05-2 | C20H22N8O5 | 454.447 g/mol

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Specifications

Chemical Identifiers

• CAS: 59-05-2
• Molecular Formula: C20H22N8O5
• Molecular Weight (g/mol): 454.447
• MDL Number: MFCD00150847
• InChI Key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• Synonym: methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
• PubChem CID: 126941
• ChEBI: CHEBI:44185
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

• Color: Yellow
• Quantity: 100 mg
• UN Number: UN1544
• Sensitivity: Hygroscopic; Light sensitive
• Merck Index: 14,5985
• Solubility Information: Soluble in dilute HCl or dilute alkali hydroxide solutions (i;e; 0;1M NaOH); Insoluble in plain water.
• Formula Weight: 454.44
• Physical Form: Powder
• Chemical Name or Material: Methotrexate

Safety and Handling

Hazard Category	H301-H315-H319-H335-H340-H360FD
Hazard Statement	GHS H Statement H301-H360-H315-H319 Toxic if swallowed. May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.
EINECSNumber	200-413-8
RTECSNumber	MA1225000
TSCA	Yes
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only