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Methotrexate
Description
Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Specifications
Specifications
Color | Yellow |
Quantity | 100 mg |
UN Number | UN1544 |
Sensitivity | Hygroscopic; Light sensitive |
Merck Index | 14,5985 |
Solubility Information | Soluble in dilute HCl or dilute alkali hydroxide solutions (i;e; 0;1M NaOH); Insoluble in plain water. |
Formula Weight | 454.44 |
Physical Form | Powder |
Chemical Name or Material | Methotrexate |
Safety and Handling
Hazard Category | H301-H315-H319-H335-H340-H360FD |
Hazard Statement | GHS H Statement H301-H360-H315-H319 Toxic if swallowed. May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation. |
Precautionary Statement | P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c |
DOTInformation | Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S. |
EINECSNumber | 200-413-8 |
RTECSNumber | MA1225000 |
TSCA | Yes |
Recommended Storage | Store at -20°C |
RUO – Research Use Only
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