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Apexbio Technology LLC Methoxy-X04 863918-78-9 10mg
Supplier: Apexbio Technology LLC B576910
Methoxy-X04 (CAS 863918-78-9) is a fluorescent small molecule derived from Congo red and Chrysamine-G characterized by its selective affinity for amyloid-beta (A ) It penetrates the brain and binds fibrillar amyloid plaques implicated in Alzheimer s disease pathology In vitro Methoxy-X04 demonstrates comparable binding affinity to fibrillar A (Ki 26 8 nM) relative to Chrysamine-G When administered intravenously or intraperitoneally (5 10 mg/kg) in transgenic APP-PS1 mouse models it enables clear visualization of amyloid plaques by fluorescence microscopy Methoxy-X04 thus serves as a valuable probe for studying A plaque accumulation and Alzheimer s disease progression
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