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Medchemexpress LLC Methyl 5-[benzylsulfonyl-...]-2-[(4-methylphenyl)methoxy]benzoate | 1919853-46-5 | MFCD31382181 | 99.9% | 680.79 | C34H36N2O9S2 | 25 MG
SDP

Supplier:  Medchemexpress LLC HY10046225MG

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PTP1B-IN-2 is a potent small-molecule inhibitor of protein tyrosine phosphatase 1B (PTP1B) that potently inhibits the target (IC50 = 50 nM) and demonstrates cellular activity by enhancing insulin receptor β phosphorylation and increasing insulin-stimulated glucose uptake in muscle cells.

  • Potent PTP1B inhibition (IC50 50 nM).
  • High selectivity versus SHP-2 and LAR (>40-fold).
  • Improved selectivity versus TCPTP (~15-fold).
  • Enhances insulin-mediated IRβ phosphorylation in cells.
  • Increases insulin-stimulated glucose uptake in L6 myotubes.
  • High purity suitable for research use (≈99.9%).

Catalog No. 50-002-15068


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