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Cayman Chemical MethylcobalamIn 1g
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Supplier:  Cayman Chemical 291131 G

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An endogenous peptide with cardiovascular functions an agonist of NPR1/GC-A and NPR3 (Kd 7 3 and 13 pM respectively for human chimeric extracellular receptors) binds human recombinant NPR1/GC-A and NPR3 (IC50s 8 and 2 6 nM respectively) activates NPR1/GC-A and increases cGMP levels in HEK293 cells (EC50 27 nM) stimulates cGMP accumulation in bovine aortic endothelial and aortic smooth muscle cells (EC50s 9 and 17 nM respectively) relaxes PGF2a-induced contractions in isolated porcine coronary artery and rat aortic strips (IC50s 0 02 and 12 1 nM respectively) increases mean urine flow and the sodium excretion rate in rats (10 nmol/kg)

Catalog No. 50-294-1911


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