Medchemexpress LLC Methylhydroquinone | 95-71-6 | 99.9% | 124.14 | 50 G

Supplier:  Medchemexpress LLC HYW01281750G

Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM for ovine COX-1 and 52.2 μM for human recombinant COX-2. It has potential DNA damaging effects by inhibiting COX-1 to reduce prostaglandin synthesis and induce anti-inflammatory activity, as well as inducing DNA single-strand breaks. Methylhydroquinone competitively binds to the active sites of COX-1 (such as Tyr385, Met522) and interacts via non-covalent interactions. It is for research use only and not sold to patients.

• Orally active COX inhibitor.
• Inhibits ovine COX-1 with an IC50 of 480.7 μM.
• Inhibits human recombinant COX-2 with an IC50 of 52.2 μM.
• Reduces prostaglandin synthesis.
• Exerts anti-inflammatory activity.
• Induces DNA single-strand breaks.
• Competitively binds to active sites of COX-1.
• Involves non-covalent interactions.
• Appearance: Solid, white to off-white.

Catalog No. 50-004-55119