Medchemexpress LLC Methylhydroquinone | 95-71-6 | 99.9% | 124.14 | 500 G

Supplier:  Medchemexpress LLC HYW012817500G

Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM for ovine COX-1 and 52.2 μM for human recombinant COX-2. It has potential DNA damaging effects by inhibiting COX-1 to reduce prostaglandin synthesis and induce anti-inflammatory activity, and by inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions.

• Orally active COX inhibitor
• IC50s of 480.7 μM for ovine COX-1 and 52.2 μM for human recombinant COX-2
• Potential DNA damaging effects, including inducing DNA single-strand breaks
• Exerts effects by competitively binding to active sites of COX-1 and non-covalent interactions
• Induces DNA single-strand breaks and increases ornithine deoxycholate (ODC) activity and repetitive DNA synthesis (RDS) in rat gastric pyloric mucosa

Catalog No. 50-004-54969