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Apexbio Technology LLC Methylprednisolone Sodium Succinate 2375-03-3 10mg
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Catalog No. 5000062749
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Methylprednisolone sodium succinate is a synthetic glucocorticoid with anti-inflammatory and immunomodulatory activity routinely utilized as an experimental tool in inflammation immune response and neural injury studies Mechanistically it binds cytoplasmic glucocorticoid receptors modulating transcriptional activity to suppress cytokine release reduce circulating lymphocyte counts and promote apoptosis and differentiation in responsive cells In vitro assays demonstrate inhibition of neutrophil-mediated chemotaxis and suppression of reactive oxygen species production at high concentrations ( 1 mg/ml) whereas lower concentrations (0 04 0 22 mM) exhibit minimal effects The IC50 values reported for suppression of neutrophil chemiluminescence and oxidant generation are approximately in the millimolar range (around 2 7 mM) Clinically it has been studied for central nervous system injuries including spinal cord trauma

Catalog No. 50-000-62749 Supplier Apexbio Technology LLC Supplier No. B495310
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Methylprednisolone sodium succinate is a synthetic glucocorticoid with anti-inflammatory and immunomodulatory activity routinely utilized as an experimental tool in inflammation immune response and neural injury studies Mechanistically it binds cytoplasmic glucocorticoid receptors modulating transcriptional activity to suppress cytokine release reduce circulating lymphocyte counts and promote apoptosis and differentiation in responsive cells In vitro assays demonstrate inhibition of neutrophil-mediated chemotaxis and suppression of reactive oxygen species production at high concentrations ( 1 mg/ml) whereas lower concentrations (0 04 0 22 mM) exhibit minimal effects The IC50 values reported for suppression of neutrophil chemiluminescence and oxidant generation are approximately in the millimolar range (around 2 7 mM) Clinically it has been studied for central nervous system injuries including spinal cord trauma

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