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Mevastatin, Tocris Bioscience™

Catalog No. 152650
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Catalog No. Quantity
15-265-0 50 mg
15-261-0 10 mg
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Catalog No. 15-265-0 Supplier R&D Systems Supplier No. 1526/50
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Description

HMG-CoA reductase inhibitor

Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo. Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Inactive lactam prodrug of mevastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Chemical Identifiers

CAS 73573-88-3
Molecular Formula C23H34O5
Molecular Weight (g/mol) 390.52
MDL Number MFCD05662341
InChI Key AJLFOPYRIVGYMJ-INTXDZFKSA-N
Synonym mevastatin, compactin, mevastatinum, mevastatina, mevastatine, mevastatinum inn-latin, antibiotic ml 236b, mevastatin inn, compactin penicillium, mevastatine inn-french
PubChem CID 64715
ChEBI CHEBI:34848
IUPAC Name (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Specifications

Quantity 50 mg
Formula Weight 390.52
Percent Purity >98%
Chemical Name or Material Mevastatin

Safety and Handling

Recommended Storage Store at Room Temperature
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