AG Scientific Inc MG-132, 1 MG

Supplier:  AG Scientific Inc M11571MG

MG-132, also known as Z-Leu-leu-leu-al, is a potent, cell-permeable, reversible, and selective 26S proteasome inhibitor and calpain inhibitor. The inhibitor is used to interfere with degradation of intracellular proteins involved in inflammatory processes and cell cycle regulation. The proteasome inhibitor reduces the degradation of IkBa, and thus it inhibits TNF-a induced NF-kB activation.MG-132 has anticancer properties. It activates c-Jun N-terminal kinase (JNK1), initiating apoptosis. It also affects various human cancer cell lines irrespective of their p53 status and is more effective in combination with drugs such as doxorubicin and etoposide.CAS Number: 133407-82-6Molecular Weight: 475.6 DaChemical Formula: C26H41N3O5Solubility: 45 mg/mL in DMSO, 45 mg/mL in DMF, 45 mg/mL in Ethanol.Storage Temperature: -20CResearch or further manufacturing use only, not for food or drug use.

Catalog No. 50-223-6986