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Apexbio Technology LLC MG-132 133407-82-6 25mg
Supplier: Apexbio Technology LLC A258525
MG-132 (CAS 133407-82-6) is a peptide aldehyde that acts as a proteasome inhibitor It targets the proteolytic activity of the ubiquitin-proteasome system triggering intracellular accumulation of proteins subsequent reactive oxygen species (ROS) production glutathione depletion mitochondrial dysfunction and cytochrome c release leading to apoptosis In vitro studies show MG-132 inhibits growth in various cancer cell lines including A549 lung carcinoma (IC50 20 M) and HeLa cervical cancer (IC50 5 M) through cell-cycle arrest predominantly at G1 and G2/M phases Thus MG-132 is commonly utilized in apoptosis research and cell-cycle regulation studies
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