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Apexbio Technology LLC MG 149 1243583-85-8 25mg
Supplier: Apexbio Technology LLC B327625
MG 149 (CAS 1243583-85-8) is a small molecule inhibitor of histone acetyltransferases (HATs) exhibiting selectivity for MYST family members Tip60 and MOF with reported IC50 values of 74 M and 47 M respectively As an alkylsalicylate derivative MG 149 competitively binds to the acetyl-CoA pocket of Tip60 thereby impeding its enzymatic activity In cell-based assays using HeLa nuclear extracts MG 149 inhibited HAT activity displaying more pronounced effects on histone H3 acetylation compared to H4 Additionally transcriptomic analyses indicate that MG 149 modulates p53 and NF- B signaling pathways highlighting its utility in studying epigenetic regulation and signaling in cellular models
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