Medchemexpress LLC Mi-1061 Tfa | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 25MG

Supplier:  Medchemexpress LLC HY125858A25MG

MI-1061 TFA is the trifluoroacetate (TFA) salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 protein-protein interaction. It activates p53, induces apoptosis in tumor models, and shows selective activity in p53 wild-type cell lines.

• Potent biochemical MDM2-p53 interaction inhibitor (IC50 = 4.4 nM; Ki = 0.16 nM).
• Selective cellular activity with IC50 = 100 nM in SJSA-1 and 250 nM in HCT-116 p53+/+; >10,000 nM in p53-/- cells.
• Trifluoroacetate salt presented as a solid form.
• Molecular weight 696.47 and molecular formula C32H27Cl2F4N3O6.
• Intended for research use as a tool compound to study p53 activation and antitumor effects.
• Purity listed as 97.47%.

Catalog No. 50-002-35962