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AdipoGen MI-2 [MALT1 Inhibitor] (5 mg)
SDP

Supplier:  AdipoGen AGCR13661M005

Encompass_Preferred

Chemical. CAS: 1047953-91-2. Formula: C19H17Cl3N4O3. MW: 455.7. Synthetic. Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8µM). Binds directly to MALT1 and suppresses protease function. Decreases NF-kappaB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo. In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells. Inhibits NF-kappaB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1beta/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.

Catalog No. 50-205-4041


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