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Medchemexpress LLC MI-3454 | 2134169-43-8 | 98.03% | 636.73 | 100 MG
SDP

Catalog No. 5000349002
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MI-3454 is an orally active, potent, and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. It inhibits proliferation, induces differentiation, and leads to leukemia regression in mouse models of MLL1-rearranged or NPM1-mutated leukemia by downregulating key genes.

  • Inhibits proliferation of murine bone marrow cells transformed with MLL-AF9 or Hoxa9/Meis1.
  • Downregulates HOXA9 and MEIS1 expression in human leukemic cell lines.
  • Reduces viability of leukemic cells with MLL fusion proteins (GI50 7-27 nM).
  • Blocks menin-MLL1 interaction.
  • Does not potently inhibit cytochromes P450.
  • Induces remission or regression of leukemia in MLL1-rearranged or NPM1-mutated mouse models.
  • Exhibits favorable stability in murine and human liver microsomes.
  • Shows limited ability to cross the blood-brain barrier.

Catalog No. 50-003-49002 Supplier Medchemexpress LLC Supplier No. HY136360100MG
May include imposed supplier surcharges.
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MI-3454 is an orally active, potent, and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. It inhibits proliferation, induces differentiation, and leads to leukemia regression in mouse models of MLL1-rearranged or NPM1-mutated leukemia by downregulating key genes.

  • Inhibits proliferation of murine bone marrow cells transformed with MLL-AF9 or Hoxa9/Meis1.
  • Downregulates HOXA9 and MEIS1 expression in human leukemic cell lines.
  • Reduces viability of leukemic cells with MLL fusion proteins (GI50 7-27 nM).
  • Blocks menin-MLL1 interaction.
  • Does not potently inhibit cytochromes P450.
  • Induces remission or regression of leukemia in MLL1-rearranged or NPM1-mutated mouse models.
  • Exhibits favorable stability in murine and human liver microsomes.
  • Shows limited ability to cross the blood-brain barrier.

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