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Medchemexpress LLC MI-463 | 1628317-18-9 | 99.7% | 484.54 | 1 ML
Supplier: Medchemexpress LLC HY1980910MM/1ML
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.
- Effectively inhibits the menin-mLL-AF9 interaction at sub-micromolar concentrations in mammalian cells.
- Achieves high level in peripheral blood following a single intravenous or oral dose, with high oral bioavailability (45%).
- Induces strong inhibition of tumor growth with once daily intraperitoneal (i.p.) administration.
- Reduces expression of mLL fusion protein target genes, HOXA9 and MEIS1.
- Delays progression of mLL leukemia in murine models through on-target activity without causing toxicity.
- Leads to a substantial delay in leukemia progression in MV4;11 xenograft recipient mice.
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