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Medchemexpress LLC MI-538 | 1857417-10-7 | 98.2% | 566.60 | 1 ML
Supplier: Medchemexpress LLC HY1981010MM/1ML
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits menin and MLL fusion proteins interaction
- Potent cellular activity with improved binding affinity to menin
- Strong down-regulation of Hoxa9 and Meis1 genes expression
- Reduces tumor volume by approximately 80% in mice xenograft models
- Improved exposure (AUC values), Cmax, and lowest clearance
- Half-life: approximately 1.6 hours
- Oral bioavailability: approximately 50%
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