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Medchemexpress LLC MI-538 | 1857417-10-7 | 98.2% | 566.60 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY19810100MG

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MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It offers selective inhibition of MLL leukemia cells and demonstrates efficacy in vivo.

  • Inhibits proliferation of MLL leukemia cells
  • Binds to menin with low nanomolar affinity
  • Downregulates Hoxa9 and Meis1 gene expression
  • Reduces MV4;11 tumor volume in mice xenografts
  • Exhibits high oral bioavailability

Catalog No. 50-004-00466


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