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Apexbio Technology LLC Midodrine (hydrochloride) 43218-56-0 250mg
Supplier: Apexbio Technology LLC C4493250
Midodrine hydrochloride (CAS 43218-56-0) is a prodrug that is metabolized to desglymidodrine a selective agonist of 1-adrenergic receptors It exhibits binding affinities (Ki) of 2 M 6 9 M and 1 7 M for the 1A 1B and 1D receptor subtypes respectively Activation of these receptors mediates vasoconstriction in arteriolar and venous smooth muscle resulting in increased vascular tone and blood pressure Preclinical studies have also shown that central administration of midodrine affects thermoregulation and locomotor activity in animal models Research applications include investigation of adrenergic signaling cardiovascular regulation and combination therapy for refractory ascites
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