Medchemexpress LLC Mifamurtide (TFA) | 98.0% | 1351.52 | 1 MG

Supplier:  Medchemexpress LLC 1MGHY13682C

Mifamurtide TFA (MTP-PE TFA) is an analog of the muramyl dipeptide (MDP) that functions as a nonspecific immunomodulator by stimulating the immune response, activating macrophages and monocytes. It is a specific ligand for NOD2 and acts as an insulin sensitizer, with potential applications in rare disease and osteosarcoma research.

• Induces reduction of MG63 cell numbers when co-cultured with macrophages.
• Increases M1 polarization marker iNOS and M2 polarization marker CD206 mRNAs.
• Increases pro-inflammatory (IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines.
• Activates macrophages and monocytes, leading to upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines.
• Shows a trend of diminished spontaneous lung metastasis dissemination in osteosarcoma models.
• Improves glucose tolerance during endotoxemia and in HFD-fed mice.

Catalog No. 50-003-65248