Milrinone, 98+%

Catalog No.	Quantity
AAJ62659MF	50 mg
AAJ62659MA	10 mg

Catalog No. AAJ62659MF Supplier Thermo Scientific Chemicals Supplier No. J62659MF

Description

Potent cAMP-specific phosphodiesterase inhibitor | CAS: 78415-72-2 | C12H9N3O | 211.224 g/mol

It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.

Solubility
Soluble in DMSO. Insoluble in water.

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 78415-72-2
• Molecular Formula: C12H9N3O
• Molecular Weight (g/mol): 211.224
• MDL Number: MFCD00133539
• InChI Key: PZRHRDRVRGEVNW-UHFFFAOYSA-N
• Synonym: milrinone, primacor, corotrope, corotrop, milrinona, milrinonum, milrinonum latin, milrinona spanish, milrila, unii-ju9yax04c7
• PubChem CID: 4197
• ChEBI: CHEBI:50693
• IUPAC Name: 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
• SMILES: CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

• Melting Point: 264°C
• Color: White
• Quantity: 50 mg
• UN Number: UN2811
• Merck Index: 14,6197
• Solubility Information: Soluble in DMSO; Insoluble in water.
• Formula Weight: 211.22
• Percent Purity: ≥98%
• Physical Form: Powder
• Chemical Name or Material: Milrinone

Safety and Handling

Hazard Category	H301+H311+H331
Hazard Statement	GHS H Statement H300-H311-H331 Fatal if swallowed. Toxic in contact with skin. Toxic if inhaled.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P312-P330-P361-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	278-903-6
RTECSNumber	DW1762000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only