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Apexbio Technology LLC MIM1 509102-00-5 10mg
Supplier: Apexbio Technology LLC A446510
MIM1 (CAS 509102-00-5) is a selective small molecule inhibitor targeting the BH3-binding groove of MCL-1 an anti-apoptotic BCL-2 family protein By binding competitively to MCL-1 MIM1 disrupts its interaction with pro-apoptotic BH3-only proteins thereby neutralizing MCL-1-mediated inhibition of apoptosis In biochemical assays MIM1 displayed IC50 values of 4 7 4 8 M for competing with FITC-MCL-1 SAHBA and FITC-BID BH3 peptides In cellular models of B-ALL MIM1 induced caspase activation and cell death specifically in MCL-1-dependent cells with minimal effects on BCL-XL-dependent counterparts MIM1 is valuable for investigating the role of MCL-1 in apoptosis and for evaluating therapeutic strategies in MCL-1-driven malignancies
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