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Medchemexpress LLC Mitiglinide (calcium) | 145525-41-3 | 98.8% | 334.44 | 10 MM 1 ML
SDP

Catalog No. 5000385958
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Mitiglinide Calcium (KAD-1229 anhydrous) is an insulinotropic agent and an ATP-sensitive K+ (KATP) channel antagonist. It is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel) and can be used for the research of type 2 diabetes.

  • ATP-sensitive K+ (KATP) channel antagonist
  • Highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel)
  • Can be used for the research of type 2 diabetes
  • Inhibits Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) in COS-1 cells
  • Does not significantly inhibit Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (>10 μM) in COS-1 cells
  • Suppresses the increase in plasma glucose levels after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load in pregnant Wistar rats at doses of 1-3 mg/kg (p.o.)

Catalog No. 50-003-85958 Supplier Medchemexpress LLC Supplier No. HY1739810MM/1ML
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Mitiglinide Calcium (KAD-1229 anhydrous) is an insulinotropic agent and an ATP-sensitive K+ (KATP) channel antagonist. It is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel) and can be used for the research of type 2 diabetes.

  • ATP-sensitive K+ (KATP) channel antagonist
  • Highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel)
  • Can be used for the research of type 2 diabetes
  • Inhibits Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) in COS-1 cells
  • Does not significantly inhibit Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (>10 μM) in COS-1 cells
  • Suppresses the increase in plasma glucose levels after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load in pregnant Wistar rats at doses of 1-3 mg/kg (p.o.)

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