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Cayman Chemical MItochondrIal ComP I AcTV 10mL
Supplier: Cayman Chemical 70093110 ML
An MC1R antagonist (IC50 7.23 nM) selective for MC1R over MC2R (IC50 10000 nM) but does antagonize 5-HT2B and 5-HT1A receptors (IC50s 9.66 and 16.9 nM respectively) inhibits MCH-induced [35S]GTPYS binding and calcium influx in HEK293 cells expressing human MC1R at 3 nM reduces stress-induced decreases in the time spent in the open arms of the elevated plus maze in mice at 1 3 and 10 mg/kg decreases immobility time in the forced swim test in mice
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