Cayman Chemical MItochondrl Complx V NADH 3mg

Supplier:  Cayman Chemical 7010033 MG

A GC-A positive allosteric modulator induces the production of cGMP in the presence (EC50 0.45 UM) but not the absence of ANP in HEK293 cells expressing human GC-A selective for GC-A over GC-B in HEK293 cells expressing the human receptors at 10 UM binds to the GC-A extracellular domain (Kd 397 nM) and enhances the binding of ANP to the GC-A extracellular domain in cell-free assays enhances ANP-induced production of cGMP in primary human renal proximal tubular cells visceral adipocytes and cardiomyocytes from 1-10 UM inhibits TGF-ß1-induced hypertrophy of primary human cardiomyocytes in combination with ANP induces cGMP production in GC-A-expressing HEK293 cells incubated with plasma isolated from patients with hypertension or heart failure

Catalog No. 50-289-3636