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Apexbio Technology LLC Mitoxantrone HCl(Synonyms: Mitoxantrone hydrochloride, Novantrone, DHAD, Mitoxantrone HCl, Mitoxantrone dihydrochloride), 10mM (in 1mL DMSO), CAS: 70476-82-3.
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Catalog No. 5000060184
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Mitoxantrone HCl (CAS 70476-82-3) is an antineoplastic small molecule inhibitor targeting DNA topoisomerase II (Topo-II) Topo-II enzymes manage DNA topology during replication and transcription facilitating chromosome segregation and relieving torsional stress Mitoxantrone interferes with Topo-II-mediated DNA cleavage and ligation inducing double-strand DNA breaks and chromatin rearrangement thus disrupting DNA synthesis and cell cycle progression It modulates activity of immune cells including T cells B cells and macrophages Research demonstrates mitoxantrone s apoptotic or senescence-inducing effects in normal human cell models Its uses in biomedical research include studies on leukemia multiple sclerosis and pancreatic cancer cell viability

Catalog No. 50-000-60184 Supplier Apexbio Technology LLC Supplier No. B21145.1
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Mitoxantrone HCl (CAS 70476-82-3) is an antineoplastic small molecule inhibitor targeting DNA topoisomerase II (Topo-II) Topo-II enzymes manage DNA topology during replication and transcription facilitating chromosome segregation and relieving torsional stress Mitoxantrone interferes with Topo-II-mediated DNA cleavage and ligation inducing double-strand DNA breaks and chromatin rearrangement thus disrupting DNA synthesis and cell cycle progression It modulates activity of immune cells including T cells B cells and macrophages Research demonstrates mitoxantrone s apoptotic or senescence-inducing effects in normal human cell models Its uses in biomedical research include studies on leukemia multiple sclerosis and pancreatic cancer cell viability

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