Apexbio Technology LLC Mitoxantrone HCl(Synonyms: Mitoxantrone hydrochloride, Novantrone, DHAD, Mitoxantrone HCl, Mitoxantrone dihydrochloride), 10mM (in 1mL DMSO), CAS: 70476-82-3.

Supplier:  Apexbio Technology LLC B21145.1

Mitoxantrone HCl (CAS 70476-82-3) is an antineoplastic small molecule inhibitor targeting DNA topoisomerase II (Topo-II) Topo-II enzymes manage DNA topology during replication and transcription facilitating chromosome segregation and relieving torsional stress Mitoxantrone interferes with Topo-II-mediated DNA cleavage and ligation inducing double-strand DNA breaks and chromatin rearrangement thus disrupting DNA synthesis and cell cycle progression It modulates activity of immune cells including T cells B cells and macrophages Research demonstrates mitoxantrone s apoptotic or senescence-inducing effects in normal human cell models Its uses in biomedical research include studies on leukemia multiple sclerosis and pancreatic cancer cell viability

Catalog No. 50-000-60184