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Medchemexpress LLC Mitraphylline | 509-80-8 | 10 MG
Supplier: Medchemexpress LLC HYN694610MG
Mitraphylline is the major pentacyclic oxindolic alkaloid found in Uncaria tomentosa. It inhibits lipopolysaccharide-mediated activation of primary human neutrophils and exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can also inhibit interleukin release in vivo.
- Purity: 99.30%
- Appearance: solid, white to off-white
- Solubility (in vitro): 6.76 mg/mL in DMSO (18.35 mM); requires ultrasonic
- Storage: 4°C, sealed, away from moisture and light
- In solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
- Reduces NO production and downregulates pro-inflammatory cytokines in human LPS-activated neutrophils
- Exhibits antiproliferative activity in GAMG (IC50 = 20.05 μM) and SKN-BE cells
- Impairs TNF-α liberation and inhibits IL-1α/β in mice in vivo
- For research use only
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