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Medchemexpress LLC MK-0812 (Succinate) | 851916-42-2 | 99.9% | C28H40F3N3O7 | 1 ML
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Supplier:  Medchemexpress LLC HY50669A10MM/1ML

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MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2. It is for research use only and not sold to patients. Key features include:

  • Completely blocks MCP-1 mediated responses (IC50 3.2 nM)
  • Inhibits 125I-MCP-1 binding on isolated monocytes (IC50 4.5 nM)
  • Inhibits monocyte shape change in rhesus blood (IC50 8 nM)
  • Reduces frequency of Ly6G-Ly6Chi monocytes in peripheral blood
  • Causes a dose-dependent reduction in circulating Ly6Chi monocytes
  • Elevates CCR2 ligand CCL2

Catalog No. 50-003-57896


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