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Medchemexpress LLC MK-0812 (succinate) | 851916-42-2 | 99.9% | C28H40F3N3O7 | 5 MG
Supplier: Medchemexpress LLC HY50669A5MG
MK-0812 succinate is a potent and selective CCR2 antagonist with high affinity. It completely blocks all MCP-1 mediated responses in a concentration-dependent manner. This compound is intended for research use only.
- Potent and selective CCR2 antagonist with high affinity
- Completely blocks all MCP-1 mediated responses (IC50 3.2 nM)
- Inhibits 125I-MCP-1 binding on isolated monocytes (IC50 4.5 nM)
- Inhibits MCP-1 induced monocyte shape change in whole blood assays (IC50 8 nM)
- Reduces Ly6G-Ly6Chi monocytes in peripheral blood in vivo
- Causes dose-dependent reduction in circulating Ly6Chi monocytes in vivo
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