Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC MK-1775 955365-80-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A57555.1
MK-1775 (CAS 955365-80-7) is a selective inhibitor targeting Wee1 kinase a nuclear Ser/Thr kinase involved in regulating entry into mitosis Mechanistically it inhibits Wee1-mediated Tyr15 phosphorylation of cyclin-dependent kinase 1 (CDC2) thus activating CDC2 and disrupting the G2 DNA damage checkpoint MK-1775 exhibits potent inhibition of Wee1 kinase with an in vitro IC50 of 5 2 nM and demonstrates substantial selectivity over related kinases including Myt1 In cell models harboring mutant p53 (e g WiDr) co-treatment with MK-1775 sensitizes tumor cells to DNA-damaging agents such as gemcitabine carboplatin and cisplatin highlighting its utility in cancer research
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?