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Apexbio Technology LLC MK-1775 955365-80-7 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A57555.1

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MK-1775 (CAS 955365-80-7) is a selective inhibitor targeting Wee1 kinase a nuclear Ser/Thr kinase involved in regulating entry into mitosis Mechanistically it inhibits Wee1-mediated Tyr15 phosphorylation of cyclin-dependent kinase 1 (CDC2) thus activating CDC2 and disrupting the G2 DNA damage checkpoint MK-1775 exhibits potent inhibition of Wee1 kinase with an in vitro IC50 of 5 2 nM and demonstrates substantial selectivity over related kinases including Myt1 In cell models harboring mutant p53 (e g WiDr) co-treatment with MK-1775 sensitizes tumor cells to DNA-damaging agents such as gemcitabine carboplatin and cisplatin highlighting its utility in cancer research

Catalog No. 50-000-61825


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