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Apexbio Technology LLC MK-2206 dihydrochloride 1032350-13-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30105.1
MK-2206 dihydrochloride (CAS 1032350-13-2) is a selective inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 This compound acts by suppressing phosphorylation of Akt at critical residues Thr308 and Ser473 thus effectively inhibiting the downstream Akt signaling pathway By disrupting Akt-mediated signaling MK-2206 promotes apoptosis in cancer cells and enhances susceptibility to chemotherapy agents In research contexts MK-2206 has demonstrated enhanced tumor-cell sensitivity when combined with etoposide or rapamycin highlighting its utility in cancer biology studies and therapy evaluations
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