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Apexbio Technology LLC MK-2461 917879-39-1 10mM (in 1mL DMSO)
SDP

Catalog No. 5000095842
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MK-2461 (CAS 917879-39-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases including c-Met (HGFR) Flt1 Flt3 Ron PDGFR and Mer with reported IC50 values of 2 5 nM 10 nM 22 nM 7 nM and 24 nM respectively c-Met frequently overexpressed or mutated in various cancers regulates cell proliferation survival migration invasion and angiogenesis In vitro MK-2461 inhibits hepatocyte growth factor (HGF)/c-Met-dependent mitogenesis cell migration scattering and tubulogenesis In mouse xenograft models of c-Met-driven tumors oral administration of MK-2461 significantly suppresses c-Met signaling and tumor growth MK-2461 is used in oncology research to investigate pathways and therapeutic strategies involving aberrant c-Met signaling

Catalog No. 50-000-95842 Supplier Apexbio Technology LLC Supplier No. A84765.1
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MK-2461 (CAS 917879-39-1) is a small molecule inhibitor targeting multiple receptor tyrosine kinases including c-Met (HGFR) Flt1 Flt3 Ron PDGFR and Mer with reported IC50 values of 2 5 nM 10 nM 22 nM 7 nM and 24 nM respectively c-Met frequently overexpressed or mutated in various cancers regulates cell proliferation survival migration invasion and angiogenesis In vitro MK-2461 inhibits hepatocyte growth factor (HGF)/c-Met-dependent mitogenesis cell migration scattering and tubulogenesis In mouse xenograft models of c-Met-driven tumors oral administration of MK-2461 significantly suppresses c-Met signaling and tumor growth MK-2461 is used in oncology research to investigate pathways and therapeutic strategies involving aberrant c-Met signaling

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