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Medchemexpress LLC MK-2461 | 917879-39-1 | 99.3% | C24H25N5O5S | 100 MG
SDP

Catalog No. 5000357709
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MK-2461 is an ATP-competitive, selective, and orally active inhibitor of wild-type and mutant c-Met. It also inhibits Ron and Flt1, demonstrating selectivity for c-MET over other kinases. This compound can be used in the study of various cancers, such as gastric cancer.

  • Inhibits phosphorylation of c-Met, AKT, and ERK1/2
  • More potent against autophosphorylation of Y1349 and Y1365
  • Effective against multiple c-Met mutants
  • Inhibits phosphorylation of FGFR2 and PDGFR-α
  • Suppresses HGF-induced cell mitogenesis
  • Inhibits IL-3-independent cell growth
  • Suppresses c-Met signaling and tumor growth in murine xenograft models
  • Achieves up to 90% tumor growth inhibition in specific xenograft models

Catalog No. 50-003-57709 Supplier Medchemexpress LLC Supplier No. HY50703100MG
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MK-2461 is an ATP-competitive, selective, and orally active inhibitor of wild-type and mutant c-Met. It also inhibits Ron and Flt1, demonstrating selectivity for c-MET over other kinases. This compound can be used in the study of various cancers, such as gastric cancer.

  • Inhibits phosphorylation of c-Met, AKT, and ERK1/2
  • More potent against autophosphorylation of Y1349 and Y1365
  • Effective against multiple c-Met mutants
  • Inhibits phosphorylation of FGFR2 and PDGFR-α
  • Suppresses HGF-induced cell mitogenesis
  • Inhibits IL-3-independent cell growth
  • Suppresses c-Met signaling and tumor growth in murine xenograft models
  • Achieves up to 90% tumor growth inhibition in specific xenograft models

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