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Medchemexpress LLC MK-28 | 864388-65-8 | >99.8% | 396.44 | 50 MG
Supplier: Medchemexpress LLC HY13720750MG
MK-28 is a potent and selective PERK activator with remarkable pharmacokinetic properties and high BBB penetration in mice. It improves systemic function and survival in R6/2 mice and induces increased levels of eIF2α-P in the mouse brain striatum. It also significantly improves motor and executive functions and delays death onset in R6/2 mice without observed toxicity.
- Demonstrates PERK selectivity on a 391-kinase panel
- Rescues cells from ER stress-induced apoptosis
- Increases ATF4 protein levels significantly, up to 2.5-fold
- Significantly increases CHOP and GADD34 mRNA levels
- Minimal effect on EIF2AK1 (HRI) or EIF2AK2 (PKR)
- Activates EIF2AK4 (GCN2)
- Improves systemic function and survival in R6/2 mice
- Induces increased levels of eIF2α-P in the mouse brain striatum
- Significantly enhances motor and executive functions
- Delays death onset in R6/2 mice with no observed toxicity
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