Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Mk-28 | 864388-65-8 | 99.88% | 396.44 | 100 MG
Supplier: Medchemexpress LLC HY137207100MG
MK-28 is a potent and selective PERK activator that demonstrates significant pharmacokinetic properties and high blood-brain barrier (BBB) penetration in mice. It has been shown to rescue cells from ER stress-induced apoptosis in vitro and improve systemic function and survival in R6/2 mice, an animal model for Huntington's disease. MK-28 also enhances motor and executive functions and delays the onset of death in R6/2 mice without causing toxicity.
- Potent and selective PERK activator
- Exhibits significant pharmacokinetic properties
- High blood-brain barrier (BBB) penetration in mice
- Rescues cells from ER stress-induced apoptosis in vitro
- Improves systemic function and survival in R6/2 mice
- Enhances motor and executive functions and delays death onset in R6/2 mice
- Activates EIF2AK4 (GCN2)
- Has little or no effect on EIF2AK1 (HRI) or EIF2AK2 (PKR)
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?