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Apexbio Technology LLC MK-571 115104-28-4 50mg
Supplier: Apexbio Technology LLC B702350
MK-571 (CAS 115104-28-4) also known as L-660711 is a selective antagonist of the leukotriene D4 (LTD4) receptor a G protein-coupled receptor activated by cysteinyl leukotrienes involved in inflammatory responses MK-571 demonstrates high affinity for the LTD4 receptor with reported Ki values of 0 22 nM in guinea pig lung and 2 1 nM in human lung membranes It effectively antagonizes LTD4- and LTE4-induced contractions in guinea pig and human airway tissues as indicated by pA2 values ranging from 8 5 to 10 5 In vivo MK-571 reduces airway hyperresponsiveness and leukocyte infiltration in animal models of pulmonary inflammation Additionally MK-571 acts as a specific inhibitor of multidrug resistance protein 1 (MRP1) supporting its use in studies of leukotriene signaling and drug transport mechanisms
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