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Apexbio Technology LLC MK-571 sodium salt hydrate 115103-85-0 50mg
Supplier: Apexbio Technology LLC B803150
MK-571 sodium salt hydrate (CAS 115103-85-0) is an antagonist of the cysteinyl-leukotriene type 1 receptor (CysLT1) a cell-surface receptor mediating allergic and hypersensitivity responses via cysteinyl leukotrienes In addition MK-571 acts as an inhibitor of multidrug resistance-associated protein 2 (ABCC2/Mrp2) commonly employed in vitro to investigate Mrp2-mediated efflux of xenobiotics and conjugates in epithelial cells Experimental evidence with Caco-2/TC7 cells indicates MK-571 also inhibits phase-2 conjugation of flavonols interfering competitively with glucuronide formation Its utilization thus spans immune-related receptor signaling studies and characterizing cellular drug transport mechanisms
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