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Medchemexpress LLC MK-8245 Trifluoroacetate | 1415559-41-9 | 98.5% | 1 MG
Supplier: Medchemexpress LLC HY130771MG
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with anti-diabetic and anti-dyslipidemic efficacy. It demonstrates high potency with an IC50 of 1 nM for human SCD1 and 3 nM for rat and mouse SCD1, and selectively targets Δ-5 and Δ-6 desaturases. Its tetrazole acetic acid moiety facilitates OATPs recognition and liver-targeting.
- Liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)
- Potent inhibition with IC50 of 1 nM for human SCD1
- Shows anti-diabetic and anti-dyslipidemic efficacy
- Tetrazole acetic acid moiety aids OATPs recognition and liver-targeting
- Exhibits significant SCD inhibition in rat hepatocyte assay (IC50 of 68 nM)
- Displays highly selective activity for Δ-5 and Δ-6 desaturases
- Concentrated in the liver in vivo, with low exposure in other tissues
- Improves glucose clearance in eDIO mice
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