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Apexbio Technology LLC MK-8745 885325-71-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A88075.1
MK-8745 (CAS 885325-71-3) is a small-molecule inhibitor targeting Aurora A kinase a serine/threonine kinase regulating chromosomal segregation during mitosis Aberrant Aurora A activity correlates with cancer progression In preclinical studies MK-8745 suppresses Aurora A kinase eliciting p53-dependent apoptosis and G2/M cell cycle arrest MK-8745 demonstrates antitumor activity in vitro across various cancer cell lines including p53-deficient and checkpoint-defective HCT116 variants and inhibits tumor growth in xenografted tumor models signifying its potential utility in cancer research targeting Aurora kinase pathways
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