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Medchemexpress LLC MK2-IN-5 acetate (Hsp25 kinase inhibitor acetate) | 99.6% | 1396.68 (free base) | 5 MG
SDP

Supplier:  Medchemexpress LLC HYP10072A5MG

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MK2-IN-5 acetate is identified as a Mk2 pseudosubstrate with a Ki of 8 μM. This compound specifically targets the protein interaction domain within the MAPK pathway and functions by inhibiting the phosphorylation of both HSP25 and HSP27.

  • Inhibits TGF-b1 induced connective tissue growth factor (CTGF) and collagen type I in primary human keloid fibroblasts (at 5-10 μM, 2 hours).
  • Decreased HSP25 phosphorylation in a ventilator-associated lung injury model with a single intraperitoneal injection (2 mg/kg).

Catalog No. 50-004-24048


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