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Enzo Life Sciences MK-886, (5mg), CAS Number: 118414-82-7
SDP

Catalog No. NC9382009
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FLAP inhibitor. Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway. Alternative Name: L-663,536. 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, Na. Formula: C27H33ClNO2S·Na. MW: 494.0. CAS Number: 118414-82-7. Purity: ≥98% (HPLC). Appearance: White solid. Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Prepare fresh solutions daily. Long Term Storage: Ambient

Catalog No. NC9382009 Supplier Enzo Life Sciences Supplier No. BMLEI2660005
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FLAP inhibitor. Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway. Alternative Name: L-663,536. 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, Na. Formula: C27H33ClNO2S·Na. MW: 494.0. CAS Number: 118414-82-7. Purity: ≥98% (HPLC). Appearance: White solid. Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Prepare fresh solutions daily. Long Term Storage: Ambient

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