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Medchemexpress LLC MKI-1 (MASTL Kinase Inhibitor-1) | 1190277-80-5 | 98.1% | 302.33 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY137552100MG

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MKI-1 is a novel small-molecule inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM. It demonstrates antitumor and radiosensitizer activities by activating PP2A in breast cancer.

  • Inhibits MASTL activity.
  • Suppresses various oncogenic properties in cancer cells.
  • Reduces both serine 62-phosphorylation and total c-Myc, alongside a decrease in ENSA phosphorylation.
  • Decreases c-Myc stability through PP2A activation.
  • Reduces tumor growth and enhances radiosensitivity in xenograft models.
  • Exhibits low gross toxicity in treated animal models, with no notable changes in body weight.

Catalog No. 50-003-50692


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