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Medchemexpress LLC ML-193 | 713121-80-3 | 99.7% | 527.59 | 1 ML
SDP

Catalog No. 5000343772
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ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, demonstrating more than 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It has been shown to improve motor and sensorimotor deficits in Parkinson's disease (PD) rat models.

  • Inhibits β-arrestin trafficking induced by L-α-lysophosphatidylinositol and ML186.
  • Decreases LPI-mediated ERK1/2 phosphorylation in U2OS cells.
  • Attenuates GPR55 agonists induced increases in hNSCs proliferation rates.
  • Attenuates ML184-induced increases in hNSCs differentiation.
  • Attenuates sensorimotor deficits and slip steps in Parkinson's disease rat models.
  • Increases motor coordination in Parkinson's disease rat models.

Catalog No. 50-003-43772 Supplier Medchemexpress LLC Supplier No. HY11012510MG
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ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, demonstrating more than 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It has been shown to improve motor and sensorimotor deficits in Parkinson's disease (PD) rat models.

  • Inhibits β-arrestin trafficking induced by L-α-lysophosphatidylinositol and ML186.
  • Decreases LPI-mediated ERK1/2 phosphorylation in U2OS cells.
  • Attenuates GPR55 agonists induced increases in hNSCs proliferation rates.
  • Attenuates ML184-induced increases in hNSCs differentiation.
  • Attenuates sensorimotor deficits and slip steps in Parkinson's disease rat models.
  • Increases motor coordination in Parkinson's disease rat models.

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