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Medchemexpress LLC ML-193 | 713121-80-3 | 99.7% | 527.59 | 1 ML
Supplier: Medchemexpress LLC HY11012510MG
ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, demonstrating more than 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It has been shown to improve motor and sensorimotor deficits in Parkinson's disease (PD) rat models.
- Inhibits β-arrestin trafficking induced by L-α-lysophosphatidylinositol and ML186.
- Decreases LPI-mediated ERK1/2 phosphorylation in U2OS cells.
- Attenuates GPR55 agonists induced increases in hNSCs proliferation rates.
- Attenuates ML184-induced increases in hNSCs differentiation.
- Attenuates sensorimotor deficits and slip steps in Parkinson's disease rat models.
- Increases motor coordination in Parkinson's disease rat models.
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