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Apexbio Technology LLC ML-323(Synonyms: ML323, ML 323, USP1 inhibitor ML323, ML-323 USP1-UAF1 inhibitor, USP1/UAF1 inhibitor ML323), 10mM (in 1mL DMSO), CAS: 1572414-83-5.
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Catalog No. 5000060140
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ML-323 (CAS 1572414-83-5) is a small molecule inhibitor selectively targeting the USP1-UAF1 deubiquitinase complex with a reported IC50 of 76 nM USP1-UAF1 participates in DNA damage response pathways by regulating ubiquitination status of proteins such as PCNA and FANCD2 In cellular assays ML-323 inhibits USP1 UAF1-mediated deubiquitination enhancing cisplatin-induced cytotoxicity in human NSCLC (H596) and osteosarcoma (U2OS) cells The molecule shows minimal cytotoxicity alone and exhibits high selectivity over other human DUBs and protease families providing a valuable research tool for DNA repair and cancer biology studies

Catalog No. 50-000-60140 Supplier Apexbio Technology LLC Supplier No. B13175.1
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ML-323 (CAS 1572414-83-5) is a small molecule inhibitor selectively targeting the USP1-UAF1 deubiquitinase complex with a reported IC50 of 76 nM USP1-UAF1 participates in DNA damage response pathways by regulating ubiquitination status of proteins such as PCNA and FANCD2 In cellular assays ML-323 inhibits USP1 UAF1-mediated deubiquitination enhancing cisplatin-induced cytotoxicity in human NSCLC (H596) and osteosarcoma (U2OS) cells The molecule shows minimal cytotoxicity alone and exhibits high selectivity over other human DUBs and protease families providing a valuable research tool for DNA repair and cancer biology studies

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