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Apexbio Technology LLC ML161 423735-93-7 10mg
Supplier: Apexbio Technology LLC A822910
ML161 (CAS 423735-93-7) is a selective small-molecule inhibitor targeting protease-activated receptor-1 (PAR1) a G protein-coupled receptor implicated in signal transduction pathways associated with tumor progression ML161 exhibits potent inhibitory activity against PAR1 with an IC of 0 26 M In human platelet assays ML161 suppresses thrombin-induced platelet activation in a dose-dependent manner as evidenced by reduced P-selectin expression Additionally ML161 inhibits P-selectin surface expression during granule secretion (EC 0 3 M) and blocks SFLLRN-stimulated platelet aggregation This compound is utilized in studies of PAR1-mediated signaling and platelet function
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