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Apexbio Technology LLC ML324 1222800-79-4 200mg
Supplier: Apexbio Technology LLC B4891200
ML324 (CAS 1222800-79-4) is a small-molecule inhibitor targeting JMJD2 histone demethylase enzymes It is designed to suppress JMJD2-mediated demethylation of histone H3 lysine 9 (H3K9) thereby affecting gene transcription regulation ML324 exerts its biological activity primarily through inhibition of JMJD2 demethylases In cell-based studies ML324 inhibits JMJD2 activity displaying an IC50 value of 920 nM In experimental models including HFF and MRC-5 cell lines it blocks immediate-early (IE) gene expression of HSV and hCMV reduces viral spread and plaque formation and inhibits HSV-1 reactivation and replication in latent infection models such as mouse neuronal ganglia explants Based on these pharmacological properties ML324 holds research potential in chromatin remodeling and antiviral therapeutic strategies
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