Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000344228

Medchemexpress LLC ML334 | 1432500-66-7 | 98.1% | 446.50 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11025810MG

Encompass_Preferred

ML334 is a potent, cell-permeable activator of NRF2, functioning by inhibiting the Keap1-NRF2 protein-protein interaction. It binds to the Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation, leading to the induction of antioxidant response elements (ARE) activity.

  • Potent, cell permeable activator of NRF2.
  • Inhibits Keap1-NRF2 protein-protein interaction.
  • Binds to Keap1 Kelch domain with a Kd of 1 μM.
  • Stimulates NRF2 expression and nuclear translocation.
  • Induces antioxidant response elements (ARE) activity.
  • Increases NQO1 and TRX1 mRNAs in HEK293 cells.
  • Enhances HO-1 mRNA expression in HEK293 cells.
  • Induces HO-1 and TRX1 proteins in HEK293 cells.

Catalog No. 50-003-44228


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.