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Medchemexpress LLC ML382 | 1646499-97-9 | 99.9% | 360.43 | 10 MG
Supplier: Medchemexpress LLC HY11028550MG
ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190 nM. It is for research use only and not sold to patients.
- Potent and selective MRGPRX1 positive allosteric modulator.
- Dose-dependently increases the potency of BAM8-22.
- Significantly increases inhibition of ICa by a low concentration of BAM8-22 in DRG neurons from MrgprX1 mice.
- Enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice.
- Dose-dependently attenuates heat hypersensitivity in MrgprX1 mice.
- Inhibits nerve injury-induced ongoing pain in MrgprX1 mice.
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