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Medchemexpress LLC ML382 | 1646499-97-9 | 99.9% | 360.43 | 10 MG
SDP

Catalog No. 5000343975
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ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190 nM. It is for research use only and not sold to patients.

  • Potent and selective MRGPRX1 positive allosteric modulator.
  • Dose-dependently increases the potency of BAM8-22.
  • Significantly increases inhibition of ICa by a low concentration of BAM8-22 in DRG neurons from MrgprX1 mice.
  • Enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice.
  • Dose-dependently attenuates heat hypersensitivity in MrgprX1 mice.
  • Inhibits nerve injury-induced ongoing pain in MrgprX1 mice.

Catalog No. 50-003-43975 Supplier Medchemexpress LLC Supplier No. HY11028550MG
May include imposed supplier surcharges.
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ML382 is a potent and selective MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1) positive allosteric modulator, with an EC50 of 190 nM. It is for research use only and not sold to patients.

  • Potent and selective MRGPRX1 positive allosteric modulator.
  • Dose-dependently increases the potency of BAM8-22.
  • Significantly increases inhibition of ICa by a low concentration of BAM8-22 in DRG neurons from MrgprX1 mice.
  • Enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice.
  • Dose-dependently attenuates heat hypersensitivity in MrgprX1 mice.
  • Inhibits nerve injury-induced ongoing pain in MrgprX1 mice.

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