Apexbio Technology LLC MLN120B 783348-36-7 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A36285.1

MLN120B (CAS 783348-36-7) is a small molecule inhibitor targeting the beta subunit of I B kinase (IKK ) an enzyme integral to the NF- B signaling pathway IKK mediates phosphorylation and subsequent degradation of the NF- B inhibitor I B thereby activating NF- B-dependent transcription involved in inflammatory and immune responses MLN120B inhibits IKK -catalyzed phosphorylation of I B (IC50 20 M) attenuating NF- B activation in multiple myeloma cell lines (RPMI 8226 INA 6 MM 1S) and reducing inflammation-induced joint damage in animal arthritis models Consequently MLN120B serves as a research tool in studying NF- B signaling-mediated disorders

Catalog No. 50-000-64281